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<\/figure>\n\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3092\u6b63\u3057\u304f\u4f7f\u7528\u3057\u3066\u3082\u601d\u3046\u3088\u3046\u306a\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u3044\u5834\u5408\u3001\u5c02\u9580\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u691c\u8a0e\u3059\u308b\u6642\u671f\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3069\u306e\u3088\u3046\u306a\u30b5\u30a4\u30f3\u304c\u300c\u5c02\u9580\u5bb6\u306b\u76f8\u8ac7\u3059\u3079\u304d\u6642\u300d\u306a\u306e\u304b\u3092\u77e5\u3063\u3066\u304a\u304f\u3053\u3068\u306f\u3001\u7f8e\u3057\u3044\u808c\u3092\u7dad\u6301\u3059\u308b\u4e0a\u3067\u3068\u3066\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n
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\u6b21\u4e16\u4ee3\u306e\u4fdd\u6e7f\u6280\u8853<\/h3>\n
\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306b\u4ee3\u308f\u308b\u3001\u3042\u308b\u3044\u306f\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3092\u8d85\u3048\u308b\u4fdd\u6e7f\u6210\u5206\u306e\u7814\u7a76\u3082\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u6d77\u6d0b\u6027\u30b3\u30e9\u30fc\u30b2\u30f3\u3001\u690d\u7269\u7531\u6765\u306e\u65b0\u3057\u3044\u591a\u7cd6\u985e\u3001\u30d0\u30a4\u30aa\u6280\u8853\u3067\u4f5c\u3089\u308c\u305f\u6b21\u4e16\u4ee3\u30da\u30d7\u30c1\u30c9\u306a\u3069\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u5b89\u5168\u6027\u306e\u9ad8\u3044\u6210\u5206\u304c\u6b21\u3005\u3068\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n
\u3053\u308c\u3089\u306e\u6280\u8853\u52d5\u5411\u3092\u77e5\u3063\u3066\u304a\u304f\u3053\u3068\u3067\u3001\u5c06\u6765\u7684\u306b\u3088\u308a\u826f\u3044\u88fd\u54c1\u304c\u767b\u5834\u3057\u305f\u969b\u306b\u3001\u9069\u5207\u306a\u5224\u65ad\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u73fe\u5728\u306e\u30b1\u30a2\u3092\u7d99\u7d9a\u3057\u306a\u304c\u3089\u3001\u65b0\u3057\u3044\u6280\u8853\u3092\u6bb5\u968e\u7684\u306b\u53d6\u308a\u5165\u308c\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u9577\u671f\u7684\u306b\u7f8e\u3057\u3044\u808c\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n
\u307e\u3068\u3081\uff1a\u8ce2\u3044\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3068\u306e\u4ed8\u304d\u5408\u3044\u65b9<\/h2>\n
\u3053\u3053\u307e\u3067\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306b\u307e\u3064\u308f\u308b\u69d8\u3005\u306a\u300c\u306a\u305c\uff1f\u300d\u3092\u79d1\u5b66\u7684\u306a\u8996\u70b9\u304b\u3089\u89e3\u304d\u660e\u304b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u91cd\u8981\u306a\u306e\u306f\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3092\u300c\u4e07\u80fd\u85ac\u300d\u3068\u3057\u3066\u904e\u5ea6\u306b\u671f\u5f85\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u305d\u306e\u7279\u6027\u3092\u6b63\u3057\u304f\u7406\u89e3\u3057\u305f\u4e0a\u3067\u3001\u8ce2\u304f\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n
\u7406\u89e3\u3059\u3079\u304d3\u3064\u306e\u30dd\u30a4\u30f3\u30c8<\/h3>\n
1. \u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306b\u306f\u660e\u78ba\u306a\u5f79\u5272\u3068\u9650\u754c\u304c\u3042\u308b<\/strong> \u8868\u9762\u4fdd\u6e7f\u3068\u4e00\u6642\u7684\u306a\u6c34\u5206\u88dc\u7d66\u306f\u5f97\u610f\u3067\u3059\u304c\u3001\u6839\u672c\u7684\u306a\u808c\u8cea\u6539\u5584\u3084\u6df1\u3044\u3057\u308f\u306e\u89e3\u6d88\u306f\u56f0\u96e3\u3067\u3059\u3002\u3053\u306e\u9650\u754c\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u9069\u5207\u306a\u671f\u5f85\u5024\u3092\u6301\u3061\u3001\u4ed6\u306e\u30b1\u30a2\u65b9\u6cd5\u3068\u306e\u4f75\u7528\u3092\u691c\u8a0e\u3067\u304d\u307e\u3059\u3002<\/p>\n2. \u500b\u4eba\u5dee\u306f\u5f53\u7136\u306e\u3053\u3068\u3067\u3042\u308b<\/strong> \u540c\u3058\u88fd\u54c1\u3067\u3082\u52b9\u679c\u306e\u611f\u3058\u65b9\u304c\u9055\u3046\u306e\u306f\u3001\u808c\u8cea\u3001\u5e74\u9f62\u3001\u751f\u6d3b\u74b0\u5883\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306a\u3069\u591a\u304f\u306e\u8981\u56e0\u304c\u5f71\u97ff\u3059\u308b\u305f\u3081\u3067\u3059\u3002\u4ed6\u4eba\u306e\u8a55\u4fa1\u306b\u60d1\u308f\u3055\u308c\u305a\u3001\u81ea\u5206\u306e\u808c\u3068\u5411\u304d\u5408\u3046\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n3. \u6b63\u3057\u3044\u4f7f\u3044\u65b9\u3067\u52b9\u679c\u306f\u5927\u304d\u304f\u5909\u308f\u308b<\/strong> \u5206\u5b50\u91cf\u306e\u9055\u3044\u3092\u7406\u89e3\u3057\u3001\u9069\u5207\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u65b9\u6cd5\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u540c\u3058\u88fd\u54c1\u3067\u3082\u52b9\u679c\u3092\u6700\u5927\u5316\u3067\u304d\u307e\u3059\u3002<\/p>\n\u4eca\u5f8c\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u6226\u7565<\/h3>\n
\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u52b9\u679c\u7684\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u6226\u7565\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u591a\u5c64\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\uff1a<\/p>\n
\u77ed\u671f\u7684\u306a\u6226\u7565\uff081-3\u30f6\u6708\uff09<\/strong>\uff1a\u9069\u5207\u306a\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306e\u9078\u629e\u3068\u6b63\u3057\u3044\u4f7f\u7528\u65b9\u6cd5\u306e\u7fd2\u5f97\u306b\u3088\u308a\u3001\u808c\u306e\u6c34\u5206\u91cf\u3068\u5168\u4f53\u7684\u306a\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u306e\u6539\u5584\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n\u4e2d\u671f\u7684\u306a\u6226\u7565\uff083-12\u30f6\u6708\uff09<\/strong>\uff1a\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3092\u542b\u3080\u7dcf\u5408\u7684\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u30eb\u30fc\u30c6\u30a3\u30f3\u306e\u78ba\u7acb\u3068\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u898b\u76f4\u3057\u306b\u3088\u308a\u3001\u808c\u8cea\u306e\u6839\u672c\u7684\u306a\u6539\u5584\u3092\u56f3\u308a\u307e\u3059\u3002<\/p>\n\u9577\u671f\u7684\u306a\u6226\u7565\uff081\u5e74\u4ee5\u4e0a\uff09<\/strong>\uff1a\u4e88\u9632\u7684\u30b1\u30a2\u3092\u91cd\u8996\u3057\u3001\u65b0\u3057\u3044\u6280\u8853\u3084\u6210\u5206\u3092\u6bb5\u968e\u7684\u306b\u53d6\u308a\u5165\u308c\u306a\u304c\u3089\u3001\u5e74\u9f62\u306b\u5fdc\u3058\u305f\u30b1\u30a2\u306e\u8abf\u6574\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n\u3042\u306a\u305f\u3089\u3057\u3044\u7f8e\u3057\u3055\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306b<\/h3>\n
\u6700\u5f8c\u306b\u3001\u6700\u3082\u91cd\u8981\u306a\u3053\u3068\u3092\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002\u7f8e\u3057\u3044\u808c\u3068\u306f\u3001\u4ed6\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u8a55\u4fa1\u3055\u308c\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u3042\u306a\u305f\u81ea\u8eab\u304c\u5065\u5eb7\u7684\u3067\u5feb\u9069\u306b\u611f\u3058\u3089\u308c\u308b\u808c\u306e\u3053\u3068\u3067\u3059\u3002\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306f\u3001\u305d\u306e\u7406\u60f3\u306b\u8fd1\u3065\u304f\u305f\u3081\u306e\u6709\u52b9\u306a\u30c4\u30fc\u30eb\u306e\u4e00\u3064\u306b\u904e\u304e\u307e\u305b\u3093\u3002<\/p>\n
\u79d1\u5b66\u7684\u306a\u77e5\u8b58\u3092\u57fa\u790e\u3068\u3057\u3066\u3001\u81ea\u5206\u306e\u808c\u306e\u58f0\u306b\u8033\u3092\u50be\u3051\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u5c02\u9580\u5bb6\u306e\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u6c42\u3081\u306a\u304c\u3089\u3001\u3042\u306a\u305f\u306b\u3068\u3063\u3066\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u65b9\u6cd5\u3092\u898b\u3064\u3051\u3066\u3044\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n
\u808c\u306f\u4e00\u65e5\u306b\u3057\u3066\u5909\u308f\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u6b63\u3057\u3044\u77e5\u8b58\u3068\u7d99\u7d9a\u7684\u306a\u30b1\u30a2\u306b\u3088\u3063\u3066\u3001\u5fc5\u305a\u826f\u3044\u65b9\u5411\u306b\u5411\u304b\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u4eca\u65e5\u3053\u306e\u8a18\u4e8b\u3067\u5f97\u305f\u77e5\u8b58\u304c\u3001\u3042\u306a\u305f\u306e\u7f8e\u3057\u3044\u808c\u3078\u306e\u7b2c\u4e00\u6b69\u3068\u306a\u308b\u3053\u3068\u3092\u5fc3\u304b\u3089\u9858\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n
\n\u53c2\u8003\u6587\u732e<\/h3>\n
[1] Papakonstantinou, E., et al. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.<\/p>\n
[2] Verdier-S\u00e9vrain, S., & Bont\u00e9, F. (2007). Skin hydration: a review on its molecular mechanisms. Journal of Cosmetic Dermatology, 6(2), 75-82.<\/p>\n
[3] Elias, P. M. (2007). The skin barrier as an innate immune element. Seminars in Immunopathology, 29(1), 3-14.<\/p>\n
[4] Ghersetich, I., et al. (1994). Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology, 33(2), 119-122.<\/p>\n
[5] Stern, R., et al. (2007). Hyaluronan fragments: an information-rich system. European Journal of Cell Biology, 86(11-12), 699-715.<\/p>\n
[6] Draelos, Z. D. (2018). The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology, 17(2), 138-144.<\/p>\n
[7] Quan, T., & Fisher, G. J. (2015). Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging. Gerontology, 61(5), 427-434.<\/p>\n
[8] Ritti\u00e9, L., & Fisher, G. J. (2015). Natural and sun-induced aging of human skin. Cold Spring Harbor Perspectives in Medicine, 5(1), a015370.<\/p>\n
[9] Brown, M. B., & Jones, S. A. (2005). Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin. Journal of the European Academy of Dermatology and Venereology, 19(3), 308-318.<\/p>\n
[10] G\u00f6llner, I., et al. (2017). Molecular weight and degree of acetylation control oligohyaluronate’s rheological properties. Biomacromolecules, 18(3), 813-823.<\/p>\n
[11] Schante, C. E., et al. (2011). Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications. Carbohydrate Polymers, 85(3), 469-489.<\/p>\n
[12] Baumann, L. (2007). Skin ageing and its treatment. Journal of Pathology, 211(2), 241-251.<\/p>\n
[13] Rawlings, A. V., & Voegeli, R. (2013). Stratum corneum proteases and dry skin conditions. Cell and Tissue Research, 351(2), 217-235.<\/p>\n
[14] Lod\u00e9n, M. (2003). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology, 4(11), 771-788.<\/p>\n
[15] Mao-Qiang, M., et al. (1995). Optimization of physiological lipid mixtures for barrier repair. Journal of Investigative Dermatology, 104(4), 654-660.<\/p>\n
[16] Fisher, G. J., et al. (2002). Mechanisms of photoaging and chronological skin aging. Archives of Dermatology, 138(11), 1462-1470.<\/p>\n
[17] Sundaram, H., et al. (2010). Facial rejuvenation using injectable hyaluronic acid products. Dermatologic Surgery, 36(3), 1769-1787.<\/p>\n
[18] Gilchrest, B. A. (2013). Photoaging. Journal of Investigative Dermatology, 133(2), E2-E6.<\/p>\n
[19] Bos, J. D., & Meinardi, M. M. (2000). The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Experimental Dermatology, 9(3), 165-169.<\/p>\n
[20] Kogan, G., et al. (2007). Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnology Letters, 29(1), 17-25.<\/p>\n
[21] Flament, F., et al. (2013). Effect of the sun on visible clinical signs of aging in Caucasian skin. Clinical, Cosmetic and Investigational Dermatology, 6, 221-232.<\/p>\n
\n[blog_parts id=”24962″]<\/p>\n
\n\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3067\u300e\u306a\u305c\u304b\u4e7e\u71e5\u3059\u308b\u300f\u8b0e\u3092\u89e3\u6c7a\uff01\u672c\u5f53\u306e\u4f7f\u3044\u65b9\u3068\u9078\u3073\u65b9\u306e\u3054\u76f8\u8ac7\u30fb\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u4e88\u7d04<\/h3>\n
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\u96fb\u8a71\u3067\u306e\u3054\u4e88\u7d04:<\/strong> 0234-25-3217<\/a>
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\u3053\u3053\u307e\u3067\u306e\u79d1\u5b66\u7684\u306a\u7406\u89e3\u3092\u8e0f\u307e\u3048\u3066\u3001\u4eca\u65e5\u304b\u3089\u3059\u3050\u306b\u5b9f\u8df5\u3067\u304d\u308b\u52b9\u679c\u7684\u306a\u4f7f\u3044\u65b9\u3092\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30b3\u30c4\u3092\u77e5\u308b\u3053\u3068\u3067\u3001\u540c\u3058\u5316\u7ca7\u6c34\u3092\u4f7f\u3063\u3066\u3082\u9a5a\u304f\u307b\u3069\u52b9\u679c\u304c\u5909\u308f\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n
\u6700\u9069\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u74b0\u5883\u4f5c\u308a<\/h3>\n
\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3059\u308b\u306b\u306f\u3001\u300c\u808c\u304c\u6c34\u5206\u3092\u53d7\u3051\u5165\u308c\u3084\u3059\u3044\u72b6\u614b\u300d\u3092\u4f5c\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u6d17\u9854\u5f8c\u3001\u808c\u306b\u6c34\u5206\u304c\u6b8b\u3063\u3066\u3044\u308b\u72b6\u614b\uff08\u7d043-5\u5206\u4ee5\u5185\uff09\u3067\u5316\u7ca7\u6c34\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u6d78\u900f\u7387\u304c\u683c\u6bb5\u306b\u5411\u4e0a\u3057\u307e\u3059[14]\u3002\u3053\u308c\u306f\u3001\u65e2\u306b\u808c\u306b\u3042\u308b\u6c34\u5206\u304c\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306e\u300c\u67b6\u3051\u6a4b\u300d\u3068\u306a\u3063\u3066\u3001\u3088\u308a\u6df1\u3044\u5c64\u3078\u306e\u6d78\u900f\u3092\u52a9\u3051\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n
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\u91cd\u306d\u4ed8\u3051\u306e\u30c6\u30af\u30cb\u30c3\u30af<\/h3>\n
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\u5404\u56de\u3067\u3001\u624b\u306e\u3072\u3089\u3067\u5316\u7ca7\u6c34\u3092\u5c11\u3057\u6e29\u3081\u3066\u304b\u3089\u808c\u306b\u62bc\u3057\u5f53\u3066\u308b\u3088\u3046\u306b\u99b4\u67d3\u307e\u305b\u308b\u3068\u3001\u6d78\u900f\u52b9\u679c\u304c\u3055\u3089\u306b\u9ad8\u307e\u308a\u307e\u3059\u3002\u6c7a\u3057\u3066\u30d1\u30c3\u30c6\u30a3\u30f3\u30b0\u3084\u5f37\u3044\u6469\u64e6\u306f\u907f\u3051\u307e\u3057\u3087\u3046\u3002<\/p>\n
\u52b9\u679c\u3092\u9ad8\u3081\u308b\u7d44\u307f\u5408\u308f\u305b\u4f7f\u3044<\/h3>\n
\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3059\u308b\u306b\u306f\u3001\u9069\u5207\u306a\u300c\u30d5\u30bf\u300d\u3092\u3059\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u5316\u7ca7\u6c34\u306e\u5f8c\u306b\u306f\u3001\u5fc5\u305a\u4e73\u6db2\u3084\u30af\u30ea\u30fc\u30e0\u3067\u6c34\u5206\u306e\u84b8\u767a\u3092\u9632\u304e\u307e\u3057\u3087\u3046\u3002\u7279\u306b\u3001\u30bb\u30e9\u30df\u30c9\u3084\u30b9\u30af\u30ef\u30e9\u30f3\u306a\u3069\u306e\u6210\u5206\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001\u4fdd\u6e7f\u52b9\u679c\u304c\u76f8\u4e57\u7684\u306b\u9ad8\u307e\u308a\u307e\u3059[15]\u3002<\/p>\n
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\u808c\u8cea\u5225\u306e\u4f7f\u3044\u5206\u3051<\/h3>\n
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3\u30f6\u6708\u4ee5\u4e0a\u7d99\u7d9a\u3057\u3066\u3082\u6539\u5584\u304c\u898b\u3089\u308c\u306a\u3044\u5834\u5408<\/strong>\uff1a\u9069\u5207\u306a\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3092\u6b63\u3057\u3044\u65b9\u6cd5\u30673\u30f6\u6708\u4ee5\u4e0a\u4f7f\u7528\u3057\u3066\u3082\u3001\u4e7e\u71e5\u611f\u3084\u5c0f\u3058\u308f\u306e\u6539\u5584\u304c\u5168\u304f\u898b\u3089\u308c\u306a\u3044\u5834\u5408\u306f\u3001\u4ed6\u306e\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n 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\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u7523\u751f\u4fc3\u9032\u6210\u5206<\/strong>\uff1a\u808c\u81ea\u4f53\u306e\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u7523\u751f\u80fd\u529b\u3092\u9ad8\u3081\u308b\u6210\u5206\uff08\u30a2\u30bb\u30c1\u30eb\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306a\u3069\uff09\u3068\u7d44\u307f\u5408\u308f\u305b\u305f\u88fd\u54c1\u3082\u5897\u3048\u3066\u3044\u307e\u3059[20]\u3002<\/p>\n \u5c06\u6765\u7684\u306b\u306f\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u3084\u808c\u72b6\u614b\u306e\u8a73\u7d30\u306a\u5206\u6790\u306b\u57fa\u3065\u3044\u3066\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u9069\u5316\u3055\u308c\u305f\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u304c\u63d0\u4f9b\u3055\u308c\u308b\u6642\u4ee3\u304c\u6765\u308b\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u65e2\u306b\u4e00\u90e8\u306e\u4f01\u696d\u3067\u306f\u3001\u808c\u306e\u6c34\u5206\u91cf\u3084\u5f3e\u529b\u6027\u3092\u8a73\u7d30\u306b\u6e2c\u5b9a\u3057\u3001\u500b\u4eba\u306b\u6700\u9069\u306a\u6210\u5206\u914d\u5408\u3092\u63d0\u6848\u3059\u308b\u30b5\u30fc\u30d3\u30b9\u304c\u59cb\u307e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n \u7d2b\u5916\u7dda\u5bfe\u7b56\u306e\u5fb9\u5e95<\/strong>\uff1a\u808c\u8001\u5316\u306e\u7d0480%\u306f\u7d2b\u5916\u7dda\u306b\u3088\u308b\u3082\u306e\u3067\u3059[21]\u3002\u65e5\u713c\u3051\u6b62\u3081\u306e\u4f7f\u7528\u306f\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306e\u52b9\u679c\u3092\u9577\u671f\u9593\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u3082\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n \u6297\u9178\u5316\u30b1\u30a2<\/strong>\uff1a\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\u3084\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306a\u3069\u306e\u6297\u9178\u5316\u6210\u5206\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u808c\u8001\u5316\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n \u751f\u6d3b\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong>\uff1a\u8cea\u306e\u826f\u3044\u7761\u7720\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u3001\u9069\u5ea6\u306a\u904b\u52d5\u306f\u3001\u808c\u306e\u81ea\u5df1\u518d\u751f\u80fd\u529b\u3092\u9ad8\u3081\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306e\u52b9\u679c\u3092\u3088\u308a\u9577\u671f\u9593\u6301\u7d9a\u3055\u305b\u307e\u3059\u3002<\/p>\n \u74b0\u5883\u3078\u306e\u914d\u616e\u3082\u4eca\u5f8c\u91cd\u8981\u306b\u306a\u3063\u3066\u304d\u307e\u3059\u3002\u518d\u751f\u53ef\u80fd\u306a\u539f\u6599\u304b\u3089\u4f5c\u3089\u308c\u305f\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3084\u3001\u74b0\u5883\u306b\u512a\u3057\u3044\u30d1\u30c3\u30b1\u30fc\u30b8\u3092\u4f7f\u7528\u3057\u305f\u88fd\u54c1\u304c\u5897\u3048\u3066\u304a\u308a\u3001\u7f8e\u5bb9\u3068\u74b0\u5883\u4fdd\u8b77\u3092\u4e21\u7acb\u3055\u305b\u308b\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u4e3b\u6d41\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n \u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306b\u4ee3\u308f\u308b\u3001\u3042\u308b\u3044\u306f\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3092\u8d85\u3048\u308b\u4fdd\u6e7f\u6210\u5206\u306e\u7814\u7a76\u3082\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u6d77\u6d0b\u6027\u30b3\u30e9\u30fc\u30b2\u30f3\u3001\u690d\u7269\u7531\u6765\u306e\u65b0\u3057\u3044\u591a\u7cd6\u985e\u3001\u30d0\u30a4\u30aa\u6280\u8853\u3067\u4f5c\u3089\u308c\u305f\u6b21\u4e16\u4ee3\u30da\u30d7\u30c1\u30c9\u306a\u3069\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u5b89\u5168\u6027\u306e\u9ad8\u3044\u6210\u5206\u304c\u6b21\u3005\u3068\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n \u3053\u308c\u3089\u306e\u6280\u8853\u52d5\u5411\u3092\u77e5\u3063\u3066\u304a\u304f\u3053\u3068\u3067\u3001\u5c06\u6765\u7684\u306b\u3088\u308a\u826f\u3044\u88fd\u54c1\u304c\u767b\u5834\u3057\u305f\u969b\u306b\u3001\u9069\u5207\u306a\u5224\u65ad\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u73fe\u5728\u306e\u30b1\u30a2\u3092\u7d99\u7d9a\u3057\u306a\u304c\u3089\u3001\u65b0\u3057\u3044\u6280\u8853\u3092\u6bb5\u968e\u7684\u306b\u53d6\u308a\u5165\u308c\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u9577\u671f\u7684\u306b\u7f8e\u3057\u3044\u808c\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n \u3053\u3053\u307e\u3067\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306b\u307e\u3064\u308f\u308b\u69d8\u3005\u306a\u300c\u306a\u305c\uff1f\u300d\u3092\u79d1\u5b66\u7684\u306a\u8996\u70b9\u304b\u3089\u89e3\u304d\u660e\u304b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u91cd\u8981\u306a\u306e\u306f\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3092\u300c\u4e07\u80fd\u85ac\u300d\u3068\u3057\u3066\u904e\u5ea6\u306b\u671f\u5f85\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u305d\u306e\u7279\u6027\u3092\u6b63\u3057\u304f\u7406\u89e3\u3057\u305f\u4e0a\u3067\u3001\u8ce2\u304f\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n 1. \u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306b\u306f\u660e\u78ba\u306a\u5f79\u5272\u3068\u9650\u754c\u304c\u3042\u308b<\/strong> \u8868\u9762\u4fdd\u6e7f\u3068\u4e00\u6642\u7684\u306a\u6c34\u5206\u88dc\u7d66\u306f\u5f97\u610f\u3067\u3059\u304c\u3001\u6839\u672c\u7684\u306a\u808c\u8cea\u6539\u5584\u3084\u6df1\u3044\u3057\u308f\u306e\u89e3\u6d88\u306f\u56f0\u96e3\u3067\u3059\u3002\u3053\u306e\u9650\u754c\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u9069\u5207\u306a\u671f\u5f85\u5024\u3092\u6301\u3061\u3001\u4ed6\u306e\u30b1\u30a2\u65b9\u6cd5\u3068\u306e\u4f75\u7528\u3092\u691c\u8a0e\u3067\u304d\u307e\u3059\u3002<\/p>\n 2. \u500b\u4eba\u5dee\u306f\u5f53\u7136\u306e\u3053\u3068\u3067\u3042\u308b<\/strong> \u540c\u3058\u88fd\u54c1\u3067\u3082\u52b9\u679c\u306e\u611f\u3058\u65b9\u304c\u9055\u3046\u306e\u306f\u3001\u808c\u8cea\u3001\u5e74\u9f62\u3001\u751f\u6d3b\u74b0\u5883\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306a\u3069\u591a\u304f\u306e\u8981\u56e0\u304c\u5f71\u97ff\u3059\u308b\u305f\u3081\u3067\u3059\u3002\u4ed6\u4eba\u306e\u8a55\u4fa1\u306b\u60d1\u308f\u3055\u308c\u305a\u3001\u81ea\u5206\u306e\u808c\u3068\u5411\u304d\u5408\u3046\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n 3. \u6b63\u3057\u3044\u4f7f\u3044\u65b9\u3067\u52b9\u679c\u306f\u5927\u304d\u304f\u5909\u308f\u308b<\/strong> \u5206\u5b50\u91cf\u306e\u9055\u3044\u3092\u7406\u89e3\u3057\u3001\u9069\u5207\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u65b9\u6cd5\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u540c\u3058\u88fd\u54c1\u3067\u3082\u52b9\u679c\u3092\u6700\u5927\u5316\u3067\u304d\u307e\u3059\u3002<\/p>\n \u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u52b9\u679c\u7684\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u6226\u7565\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u591a\u5c64\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\uff1a<\/p>\n \u77ed\u671f\u7684\u306a\u6226\u7565\uff081-3\u30f6\u6708\uff09<\/strong>\uff1a\u9069\u5207\u306a\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306e\u9078\u629e\u3068\u6b63\u3057\u3044\u4f7f\u7528\u65b9\u6cd5\u306e\u7fd2\u5f97\u306b\u3088\u308a\u3001\u808c\u306e\u6c34\u5206\u91cf\u3068\u5168\u4f53\u7684\u306a\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u306e\u6539\u5584\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n \u4e2d\u671f\u7684\u306a\u6226\u7565\uff083-12\u30f6\u6708\uff09<\/strong>\uff1a\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u3092\u542b\u3080\u7dcf\u5408\u7684\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u30eb\u30fc\u30c6\u30a3\u30f3\u306e\u78ba\u7acb\u3068\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u898b\u76f4\u3057\u306b\u3088\u308a\u3001\u808c\u8cea\u306e\u6839\u672c\u7684\u306a\u6539\u5584\u3092\u56f3\u308a\u307e\u3059\u3002<\/p>\n \u9577\u671f\u7684\u306a\u6226\u7565\uff081\u5e74\u4ee5\u4e0a\uff09<\/strong>\uff1a\u4e88\u9632\u7684\u30b1\u30a2\u3092\u91cd\u8996\u3057\u3001\u65b0\u3057\u3044\u6280\u8853\u3084\u6210\u5206\u3092\u6bb5\u968e\u7684\u306b\u53d6\u308a\u5165\u308c\u306a\u304c\u3089\u3001\u5e74\u9f62\u306b\u5fdc\u3058\u305f\u30b1\u30a2\u306e\u8abf\u6574\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n \u6700\u5f8c\u306b\u3001\u6700\u3082\u91cd\u8981\u306a\u3053\u3068\u3092\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002\u7f8e\u3057\u3044\u808c\u3068\u306f\u3001\u4ed6\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u8a55\u4fa1\u3055\u308c\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u3042\u306a\u305f\u81ea\u8eab\u304c\u5065\u5eb7\u7684\u3067\u5feb\u9069\u306b\u611f\u3058\u3089\u308c\u308b\u808c\u306e\u3053\u3068\u3067\u3059\u3002\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5316\u7ca7\u6c34\u306f\u3001\u305d\u306e\u7406\u60f3\u306b\u8fd1\u3065\u304f\u305f\u3081\u306e\u6709\u52b9\u306a\u30c4\u30fc\u30eb\u306e\u4e00\u3064\u306b\u904e\u304e\u307e\u305b\u3093\u3002<\/p>\n \u79d1\u5b66\u7684\u306a\u77e5\u8b58\u3092\u57fa\u790e\u3068\u3057\u3066\u3001\u81ea\u5206\u306e\u808c\u306e\u58f0\u306b\u8033\u3092\u50be\u3051\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u5c02\u9580\u5bb6\u306e\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u6c42\u3081\u306a\u304c\u3089\u3001\u3042\u306a\u305f\u306b\u3068\u3063\u3066\u6700\u9069\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u65b9\u6cd5\u3092\u898b\u3064\u3051\u3066\u3044\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n \u808c\u306f\u4e00\u65e5\u306b\u3057\u3066\u5909\u308f\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u6b63\u3057\u3044\u77e5\u8b58\u3068\u7d99\u7d9a\u7684\u306a\u30b1\u30a2\u306b\u3088\u3063\u3066\u3001\u5fc5\u305a\u826f\u3044\u65b9\u5411\u306b\u5411\u304b\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u4eca\u65e5\u3053\u306e\u8a18\u4e8b\u3067\u5f97\u305f\u77e5\u8b58\u304c\u3001\u3042\u306a\u305f\u306e\u7f8e\u3057\u3044\u808c\u3078\u306e\u7b2c\u4e00\u6b69\u3068\u306a\u308b\u3053\u3068\u3092\u5fc3\u304b\u3089\u9858\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n [1] Papakonstantinou, E., et al. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.<\/p>\n [2] Verdier-S\u00e9vrain, S., & Bont\u00e9, F. (2007). Skin hydration: a review on its molecular mechanisms. Journal of Cosmetic Dermatology, 6(2), 75-82.<\/p>\n [3] Elias, P. M. (2007). The skin barrier as an innate immune element. Seminars in Immunopathology, 29(1), 3-14.<\/p>\n [4] Ghersetich, I., et al. (1994). Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology, 33(2), 119-122.<\/p>\n [5] Stern, R., et al. (2007). Hyaluronan fragments: an information-rich system. European Journal of Cell Biology, 86(11-12), 699-715.<\/p>\n [6] Draelos, Z. D. (2018). The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology, 17(2), 138-144.<\/p>\n [7] Quan, T., & Fisher, G. J. (2015). Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging. Gerontology, 61(5), 427-434.<\/p>\n [8] Ritti\u00e9, L., & Fisher, G. J. (2015). Natural and sun-induced aging of human skin. Cold Spring Harbor Perspectives in Medicine, 5(1), a015370.<\/p>\n [9] Brown, M. B., & Jones, S. A. (2005). Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin. Journal of the European Academy of Dermatology and Venereology, 19(3), 308-318.<\/p>\n [10] G\u00f6llner, I., et al. (2017). Molecular weight and degree of acetylation control oligohyaluronate’s rheological properties. Biomacromolecules, 18(3), 813-823.<\/p>\n [11] Schante, C. E., et al. (2011). Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications. Carbohydrate Polymers, 85(3), 469-489.<\/p>\n [12] Baumann, L. (2007). Skin ageing and its treatment. Journal of Pathology, 211(2), 241-251.<\/p>\n [13] Rawlings, A. V., & Voegeli, R. (2013). Stratum corneum proteases and dry skin conditions. Cell and Tissue Research, 351(2), 217-235.<\/p>\n [14] Lod\u00e9n, M. (2003). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology, 4(11), 771-788.<\/p>\n [15] Mao-Qiang, M., et al. (1995). Optimization of physiological lipid mixtures for barrier repair. Journal of Investigative Dermatology, 104(4), 654-660.<\/p>\n [16] Fisher, G. J., et al. (2002). Mechanisms of photoaging and chronological skin aging. Archives of Dermatology, 138(11), 1462-1470.<\/p>\n [17] Sundaram, H., et al. (2010). Facial rejuvenation using injectable hyaluronic acid products. Dermatologic Surgery, 36(3), 1769-1787.<\/p>\n [18] Gilchrest, B. A. (2013). Photoaging. Journal of Investigative Dermatology, 133(2), E2-E6.<\/p>\n [19] Bos, J. D., & Meinardi, M. M. (2000). The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Experimental Dermatology, 9(3), 165-169.<\/p>\n [20] Kogan, G., et al. (2007). Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnology Letters, 29(1), 17-25.<\/p>\n [21] Flament, F., et al. (2013). Effect of the sun on visible clinical signs of aging in Caucasian skin. 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