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class=\"wp-block-heading\">\u7d2b\u5916\u7dda\u5bfe\u7b56\u306e\u7d99\u7d9a<\/h4>\n<p>\u7d2b\u5916\u7dda\u306f\u808c\u306e\u8001\u5316\u3092\u4fc3\u9032\u3057\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306e\u5206\u89e3\u3082\u65e9\u3081\u3066\u3057\u307e\u3044\u307e\u3059[15]\u3002\u65bd\u8853\u90e8\u4f4d\u306b\u9650\u3089\u305a\u3001\u9854\u5168\u4f53\u306eUV\u30b1\u30a2\u3092\u7d99\u7d9a\u7684\u306b\u884c\u3046\u3053\u3068\u3067\u3001\u6cbb\u7642\u52b9\u679c\u3092\u3088\u308a\u9577\u304f\u7dad\u6301\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u65e5\u713c\u3051\u6b62\u3081\u306f\u4e00\u5e74\u4e2d\u4f7f\u7528\u3057\u3001\u5e3d\u5b50\u3084\u65e5\u5098\u3082\u6d3b\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u3053\u308c\u306f\u3001\u5927\u5207\u306a\u5199\u771f\u3092\u8272\u892a\u305b\u304b\u3089\u5b88\u308b\u305f\u3081\u306b\u984d\u7e01\u306b\u5165\u308c\u3066\u4fdd\u7ba1\u3059\u308b\u306e\u3068\u540c\u3058\u3088\u3046\u306a\u8003\u3048\u65b9\u3067\u3059\u3002<\/p>\n<h3 class=\"wp-block-heading\">\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3068\u808c\u3078\u306e\u5f71\u97ff<\/h3>\n<p>\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u4f53\u5185\u306e\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u5206\u89e3\u3092\u4fc3\u9032\u3055\u305b\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059[16]\u3002\u9069\u5ea6\u306a\u904b\u52d5\u3001\u8da3\u5473\u306e\u6642\u9593\u3001\u7791\u60f3\u3084\u6df1\u547c\u5438\u306a\u3069\u3001\u81ea\u5206\u306a\u308a\u306e\u30b9\u30c8\u30ec\u30b9\u89e3\u6d88\u6cd5\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3001\u7f8e\u5bb9\u52b9\u679c\u306e\u7dad\u6301\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u306f\u3001\u690d\u7269\u3092\u80b2\u3066\u308b\u6642\u306b\u3001\u6c34\u3084\u80a5\u6599\u3060\u3051\u3067\u306a\u304f\u3001\u9069\u5207\u306a\u74b0\u5883\u4f5c\u308a\u304c\u5927\u5207\u306a\u306e\u3068\u540c\u3058\u3067\u3059\u3002<\/p>\n<h2 class=\"wp-block-heading\" 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class=\"wp-block-heading\">\u300c\u5de6\u53f3\u5dee\u304c\u6c17\u306b\u306a\u308b\u300d\u6642\u306e\u8003\u3048\u65b9<\/h3>\n<p>\u65bd\u8853\u76f4\u5f8c\u306f\u3001\u816b\u308c\u65b9\u306b\u5de6\u53f3\u5dee\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u6ce8\u5165\u90e8\u4f4d\u306e\u8840\u7ba1\u5206\u5e03\u3084\u7b4b\u8089\u306e\u52d5\u304d\u65b9\u304c\u5de6\u53f3\u3067\u5fae\u5999\u306b\u7570\u306a\u308b\u305f\u3081\u3067\u3059[17]\u3002<\/p>\n<p>\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u816b\u308c\u304c\u5f15\u304f\u306b\u3064\u308c\u3066\u5de6\u53f3\u5dee\u3082\u76ee\u7acb\u305f\u306a\u304f\u306a\u308a\u307e\u3059\u30022\u9031\u9593\u7a0b\u5ea6\u306f\u69d8\u5b50\u3092\u898b\u3066\u3001\u305d\u308c\u3067\u3082\u6c17\u306b\u306a\u308b\u5834\u5408\u306f\u65bd\u8853\u533b\u306b\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h3 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class=\"wp-block-heading\">\u5bb6\u65cf\u3084\u53cb\u4eba\u3078\u306e\u8aac\u660e\u306e\u4ed5\u65b9<\/h3>\n<p>\u300c\u4f55\u304b\u9055\u3046\uff1f\u300d\u3068\u805e\u304b\u308c\u305f\u6642\u3001\u6b63\u76f4\u306b\u8a71\u3059\u304b\u3069\u3046\u304b\u306f\u500b\u4eba\u306e\u5224\u65ad\u3067\u3059\u3002\u7121\u7406\u306b\u96a0\u3059\u5fc5\u8981\u3082\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u30d7\u30e9\u30a4\u30d9\u30fc\u30c8\u306a\u3053\u3068\u3067\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u300c\u65b0\u3057\u3044\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u59cb\u3081\u305f\u300d\u300c\u3088\u304f\u7720\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u300d\u306a\u3069\u3001\u81ea\u7136\u306a\u7bc4\u56f2\u3067\u306e\u8aac\u660e\u3067\u5341\u5206\u3067\u3059\u3002\u5927\u5207\u306a\u306e\u306f\u3001\u3042\u306a\u305f\u81ea\u8eab\u304c\u9078\u629e\u3057\u305f\u7f8e\u5bb9\u6cd5\u306b\u81ea\u4fe1\u3092\u6301\u3064\u3053\u3068\u3067\u3059\u3002<\/p>\n<h2 class=\"wp-block-heading\" id=\"section-6fcba5\">\u7d99\u7d9a\u7684\u306a\u30b1\u30a2\u3068\u6b21\u56de\u306e\u65bd\u8853\u306b\u3064\u3044\u3066<\/h2>\n<h3 class=\"wp-block-heading\">\u52b9\u679c\u306e\u5909\u5316\u3092\u8a18\u9332\u3059\u308b\u7fd2\u6163<\/h3>\n<p>\u6708\u306b\u4e00\u5ea6\u3001\u540c\u3058\u89d2\u5ea6\u30fb\u540c\u3058\u7167\u660e\u3067\u5199\u771f\u3092\u64ae\u5f71\u3059\u308b\u7fd2\u6163\u3092\u3064\u3051\u308b\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u52b9\u679c\u306e\u5909\u5316\u3092\u5ba2\u89b3\u7684\u306b\u628a\u63e1\u3067\u304d\u307e\u3059[18]\u3002<\/p>\n<p>\u307e\u305f\u3001\u93e1\u3092\u898b\u305f\u6642\u306e\u5370\u8c61\u3084\u3001\u5468\u56f2\u304b\u3089\u306e\u53cd\u5fdc\u306a\u3069\u3082\u8a18\u9332\u3057\u3066\u304a\u304f\u3068\u3001\u6b21\u56de\u306e\u65bd\u8853\u8a08\u753b\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n<h3 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class=\"wp-block-heading\">\u4ed6\u306e\u7f8e\u5bb9\u65bd\u8853\u3068\u306e\u7d44\u307f\u5408\u308f\u305b<\/h3>\n<p>\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u6ce8\u5165\u5f8c\u3001\u4ed6\u306e\u7f8e\u5bb9\u65bd\u8853\u3092\u691c\u8a0e\u3059\u308b\u5834\u5408\u306f\u3001\u5fc5\u305a\u65bd\u8853\u533b\u306b\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u3084\u30d4\u30fc\u30ea\u30f3\u30b0\u306a\u3069\u306f\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u304c\u5b89\u5b9a\u3057\u305f\u5f8c\u306e\u65b9\u304c\u5b89\u5168\u3067\u3059[20]\u3002<\/p>\n<p>\u4e00\u822c\u7684\u306b\u3001\u4ed6\u306e\u65bd\u8853\u306f2\u9031\u9593\u4ee5\u4e0a\u9593\u9694\u3092\u7a7a\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2 class=\"wp-block-heading\" id=\"section-af945c\">\u30c8\u30e9\u30d6\u30eb\u6642\u306e\u5bfe\u5fdc\uff1a\u300c\u3044\u3064\u3082\u3068\u9055\u3046\u300d\u3092\u898b\u6975\u3081\u308b<\/h2>\n<h3 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class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n<h2 class=\"wp-block-heading\" id=\"section-fb507f\">\u53c2\u8003\u6587\u732e<\/h2>\n<p>[1] Rohrich RJ, et al. Current concepts in aesthetic facial rejuvenation: hyaluronic acid fillers. Plast Reconstr Surg. 2019;143(3):1014-1021.<\/p>\n<p>[2] DeLorenzi C. Complications of injectable fillers, part I. Aesthet Surg J. 2013;33(4):561-575.<\/p>\n<p>[3] Carruthers A, et al. A validated facial grading scale: the comprehensive grading scale for facial aging. Dermatol Surg. 2008;34 Suppl 2:S128-134.<\/p>\n<p>[4] Sundaram H, et al. Injection techniques for hyaluronic acid soft tissue fillers. Dermatol Surg. 2020;46(1):S12-S18.<\/p>\n<p>[5] Falcone SJ, et al. Hyaluronic acid dermal fillers: a comprehensive overview. Facial Plast Surg. 2017;33(1):29-34.<\/p>\n<p>[6] Beasley KL, et al. Hyaluronic acid fillers: a comprehensive review. Facial Plast Surg. 2009;25(2):86-94.<\/p>\n<p>[7] Glogau RG. Review of the use of hyaluronic acid as a soft-tissue augmentation material. Facial Plast Surg Clin North Am. 2007;15(1):63-70.<\/p>\n<p>[8] Narins RS, et al. A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for correction of nasolabial folds. Dermatol Surg. 2003;29(6):588-595.<\/p>\n<p>[9] Rzany B, et al. Avoiding and managing complications from fillers: a practical approach. Clin Plast Surg. 2006;33(4):611-625.<\/p>\n<p>[10] Tezel A, et al. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther. 2008;10(1):35-42.<\/p>\n<p>[11] Lowe NJ, et al. Hyaluronic acid skin fillers: adverse reactions and skin testing. J Am Acad Dermatol. 2001;45(6):930-933.<\/p>\n<p>[12] Kablik J, et al. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009;35 Suppl 1:302-312.<\/p>\n<p>[13] Papakonstantinou E, et al. Hyaluronic acid: a key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253-258.<\/p>\n<p>[14] Stern R, et al. Hyaluronan in cancer biology. Semin Cancer Biol. 2008;18(4):275-280.<\/p>\n<p>[15] Yoshizaki N, et al. Effects of ultraviolet irradiation on hyaluronic acid metabolism in cultured human skin fibroblasts. Arch Dermatol Res. 1997;289(4):221-226.<\/p>\n<p>[16] Russell-Goldman E, et al. The pathobiology of skin aging: new insights into an old dilemma. Am J Pathol. 2020;190(7):1356-1369.<\/p>\n<p>[17] Baumann L, et al. Dermal fillers: an update. Am J Clin Dermatol. 2018;19(2):181-193.<\/p>\n<p>[18] Carruthers J, et al. Advances in facial rejuvenation: botulinum toxin type A, hyaluronic acid dermal fillers, and combination therapies consensus recommendations. Plast Reconstr Surg. 2008;121(5 Suppl):5S-30S.<\/p>\n<p>[19] Micheels P, et al. A blanching technique for intradermal injection of the hyaluronic acid Belotero. Plast Reconstr Surg. 2013;132(4 Suppl 2):59S-68S.<\/p>\n<p>[20] Urdiales-G\u00e1lvez F, et al. Treatment of soft tissue filler complications: expert consensus recommendations. Aesthetic Plast Surg. 2018;42(2):498-510.<\/p>\n<p>[21] Beleznay K, et al. Avoiding and treating blindness from fillers: a review of the world literature. 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