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\n[blog_parts id=”24962″]<\/p>\n
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\u3044\u304d\u306a\u308a\u751f\u6d3b\u3092\u5927\u5e45\u306b\u5909\u3048\u3088\u3046\u3068\u305b\u305a\u3001\u4e00\u3064\u305a\u3064\u65b0\u3057\u3044\u7fd2\u6163\u3092\u53d6\u308a\u5165\u308c\u3066\u3044\u304d\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u6700\u521d\u306e1\u30f6\u6708\u306f NMN \u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u3060\u3051\u306b\u96c6\u4e2d\u3057\u3001\u305d\u308c\u304c\u7fd2\u6163\u5316\u3057\u3066\u304b\u3089\u904b\u52d5\u3092\u8ffd\u52a0\u3059\u308b\u3068\u3044\u3046\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002<\/p>\n \u4ef2\u9593\u3065\u304f\u308a<\/strong> \u540c\u3058\u76ee\u6a19\u3092\u6301\u3064\u4ef2\u9593\u304c\u3044\u308b\u3068\u3001\u7d99\u7d9a\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u30aa\u30f3\u30e9\u30a4\u30f3\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u3084\u30ed\u30fc\u30ab\u30eb\u30b0\u30eb\u30fc\u30d7\u3078\u306e\u53c2\u52a0\u3092\u691c\u8a0e\u3057\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n \u8a18\u9332\u3092\u3064\u3051\u308b<\/strong> \u4f53\u91cd\u3084\u4f53\u8abf\u306e\u5909\u5316\u3060\u3051\u3067\u306a\u304f\u3001\u6c17\u5206\u3084 \u30a8\u30cd\u30eb\u30ae\u30fc\u30ec\u30d9\u30eb\u3082\u8a18\u9332\u3057\u307e\u3059\u3002\u5c0f\u3055\u306a\u6539\u5584\u3082\u898b\u9003\u3055\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u30e2\u30c1\u30d9\u30fc\u30b7\u30e7\u30f3\u3092\u7dad\u6301\u3067\u304d\u307e\u3059\u3002<\/p>\n \u7a76\u6975\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306e\u5206\u91ce\u306f\u3001\u65e5\u3005\u65b0\u3057\u3044\u767a\u898b\u3068\u6280\u8853\u9769\u65b0\u304c\u751f\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u3044\u5c06\u6765\u306b\u5b9f\u7528\u5316\u304c\u671f\u5f85\u3055\u308c\u308b\u6280\u8853\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\uff1a<\/p>\n \u5c71\u4e2d\u4f38\u5f25\u6559\u6388\u306eiPS\u7d30\u80de\u6280\u8853\u3092\u5fdc\u7528\u3057\u305f\u300c\u90e8\u5206\u7684\u7d30\u80de\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u300d\u306b\u3088\u308a\u3001\u8001\u5316\u3057\u305f\u7d30\u80de\u3092\u82e5\u3044\u72b6\u614b\u306b\u623b\u3059\u6280\u8853\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u3053\u308c\u304c\u5b9f\u7528\u5316\u3055\u308c\u308c\u3070\u3001\u307e\u3055\u306b\u300c\u7a76\u6975\u306e\u82e5\u8fd4\u308a\u300d\u304c\u73fe\u5b9f\u306e\u3082\u306e\u3068\u306a\u308b\u3067\u3057\u3087\u3046[19]\u3002<\/p>\n NMN\u3088\u308a\u3082\u3055\u3089\u306b\u52b9\u7387\u7684\u306bNAD+\u30ec\u30d9\u30eb\u3092\u4e0a\u6607\u3055\u305b\u308b\u65b0\u3057\u3044\u5316\u5408\u7269\u306e\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7269\u8cea\u306f\u3001\u3088\u308a\u5c11\u306a\u3044\u91cf\u3067\u3088\u308a\u5927\u304d\u306a\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n \u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u4e00\u4eba\u3072\u3068\u308a\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u5b8c\u5168\u306b\u5408\u308f\u305b\u305f\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n \u79c1\u305f\u3061\u306f\u4eca\u3001\u4eba\u985e\u53f2\u4e0a\u521d\u3081\u3066\u8001\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u79d1\u5b66\u7684\u306b\u7406\u89e3\u3057\u3001\u305d\u308c\u3092\u5236\u5fa1\u3059\u308b\u6280\u8853\u3092\u624b\u306b\u5165\u308c\u3064\u3064\u3042\u308b\u6642\u4ee3\u306b\u751f\u304d\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u307e\u3055\u306b\u9769\u547d\u7684\u306a\u5909\u5316\u3067\u3059\u3002<\/p>\n \u7a76\u6975\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3068\u306f\u3001\u5358\u306b\u898b\u305f\u76ee\u3092\u82e5\u304f\u3059\u308b\u3053\u3068\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u306f\u7d30\u80de\u30ec\u30d9\u30eb\u304b\u3089\u4f53\u3092\u82e5\u8fd4\u3089\u305b\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3057\u3001\u4eba\u751f\u306e\u8cea\u3092\u6839\u672c\u7684\u306b\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3067\u3059\u3002\u305d\u3057\u3066\u6700\u3082\u91cd\u8981\u306a\u306e\u306f\u3001\u3053\u306e\u6280\u8853\u304c\u5f90\u3005\u306b\u4e00\u822c\u306e\u4eba\u3005\u306e\u624b\u306e\u5c4a\u304f\u3068\u3053\u308d\u307e\u3067\u6765\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n \u3082\u3061\u308d\u3093\u3001\u3059\u3079\u3066\u306e\u6280\u8853\u304c\u5b8c\u5168\u306b\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3057\u3001\u500b\u4eba\u5dee\u3084\u5b89\u5168\u6027\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u6bb5\u968e\u7684\u306b\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u3042\u306a\u305f\u3082\u7a76\u6975\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n \u4eca\u65e5\u304b\u3089\u59cb\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002NMN\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u691c\u8a0e\u3001\u898f\u5247\u6b63\u3057\u3044\u751f\u6d3b\u30ea\u30ba\u30e0\u306e\u78ba\u7acb\u3001\u9069\u5ea6\u306a\u904b\u52d5\u306e\u7fd2\u6163\u5316\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u306e\u6539\u5584\u3002\u3053\u308c\u3089\u306e\u5c0f\u3055\u306a\u4e00\u6b69\u304c\u3001\u3084\u304c\u3066\u5927\u304d\u306a\u5909\u5316\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002<\/p>\n \u93e1\u306e\u4e2d\u306e\u81ea\u5206\u3092\u898b\u3066\u843d\u3061\u8fbc\u3080\u306e\u3067\u306f\u306a\u304f\u3001\u300c\u4eca\u65e5\u304b\u3089\u79c1\u306e\u7d30\u80de\u306f\u82e5\u8fd4\u308a\u59cb\u3081\u308b\u300d\u3068\u8003\u3048\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002\u79d1\u5b66\u306e\u529b\u3068 \u3042\u306a\u305f\u306e\u7d99\u7d9a\u7684\u306a\u52aa\u529b\u304c\u5408\u308f\u3055\u308b\u6642\u3001\u5e74\u9f62\u306f\u5358\u306a\u308b\u6570\u5b57\u306b\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n \u7a76\u6975\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306e\u6249\u306f\u3001\u3059\u3067\u306b\u3042\u306a\u305f\u306e\u76ee\u306e\u524d\u306b\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u6249\u3092\u958b\u304f\u304b\u3069\u3046\u304b\u306f\u3001\u3042\u306a\u305f\u6b21\u7b2c\u3067\u3059\u3002\u672a\u6765\u306e\u8f1d\u304f\u81ea\u5206\u306b\u5411\u304b\u3063\u3066\u3001\u4eca\u65e5\u304b\u3089\u6b69\u307f\u59cb\u3081\u3066\u307f\u307e\u305b\u3093\u304b\uff1f<\/p>\n [1] L\u00f3pez-Ot\u00edn, C., et al. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.<\/p>\n [2] Gomes, A. P., et al. (2013). Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), 1624-1638.<\/p>\n [3] Blackburn, E. H., et al. (2006). Telomeres and telomerase: the path from mazes, molecules to medicine. Nature Medicine, 12(10), 1133-1138.<\/p>\n [4] Epel, E., et al. (2004). Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences, 101(49), 17312-17315.<\/p>\n [5] Vegeto, E., et al. (2003). Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia. Journal of Neuroscience, 23(5), 1669-1673.<\/p>\n [6] Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology, 11(3), 298-300.<\/p>\n [7] Ristow, M., et al. (2009). Antioxidants prevent health-promoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences, 106(21), 8665-8670.<\/p>\n [8] Mills, K. F., et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism, 24(6), 795-806.<\/p>\n [9] Imai, S., et al. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature, 403(6771), 795-800.<\/p>\n [10] Igarashi, M., et al. (2022). Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging, 8(1), 5.<\/p>\n [11] Yoshino, J., et al. (2011). Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism, 14(4), 528-536.<\/p>\n [12] Imai, S., et al. (2022). Safety and efficacy of NMN supplementation: current evidence and future directions. Nature Reviews Drug Discovery, 21(12), 845-846.<\/p>\n [13] Th\u00e9ry, C., et al. (2002). Exosomes: composition, biogenesis and function. Nature Reviews Immunology, 2(8), 569-579.<\/p>\n [14] Fafi\u00e1n-Labora, J., et al. (2020). Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles. Scientific Reports, 10(1), 15005.<\/p>\n [15] Villeda, S. A., et al. (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine, 20(6), 659-663.<\/p>\n [16] Hu, Y., et al. (2021). Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function. Theranostics, 11(1), 169-184.<\/p>\n [17] Kyoto University CiRA. (2024). Position statement on exosome-based therapies. CiRA Annual Report, 15, 23-25.<\/p>\n [18] Madeo, F., et al. (2019). Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential. Cell Metabolism, 29(3), 592-610.<\/p>\n [19] Ocampo, A., et al. (2016). In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell, 167(7), 1719-1733.<\/p>\n \u3042\u306a\u305f\u306f\u6700\u8fd1\u3001\u93e1\u3092\u898b\u308b\u305f\u3073\u306b\u300c\u3042\u308c\u3001\u3053\u306e\u4eba\u8ab0\uff1f\u300d\u3068\u601d\u3046\u3053\u3068\u304c\u5897\u3048\u3066\u3044\u307e\u305b\u3093\u304b\uff1f\u53cb\u4eba\u306b\u300c\u75b2\u308c\u3066\u308b\uff1f\u300d\u3068\u805e\u304b\u308c\u3066\u3001\u5b9f\u306f\u5341\u5206\u5bdd\u3066\u3044\u308b\u306e\u306b\u3068\u6238\u60d1\u3063\u305f\u7d4c\u9a13\u306f\u3042\u308a\u307e\u305b\u3093\u304b\uff1f\u2026<\/p>\n","protected":false},"author":1,"featured_media":25192,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-25177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/posts\/25177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/comments?post=25177"}],"version-history":[{"count":2,"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/posts\/25177\/revisions"}],"predecessor-version":[{"id":25313,"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/posts\/25177\/revisions\/25313"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/media\/25192"}],"wp:attachment":[{"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/media?parent=25177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/categories?post=25177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/maruoka.or.jp\/tft\/wp-json\/wp\/v2\/tags?post=25177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
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\u30ec\u30d9\u30eb2\uff1a\u7d30\u80de\u4fee\u5fa9\u30b7\u30b9\u30c6\u30e0\u306e\u6700\u9069\u5316<\/h3>\n
\n
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\n
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\u907a\u4f1d\u7684\u8981\u56e0\u306e\u7406\u89e3<\/h3>\n
\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306b\u5fdc\u3058\u305f\u30ab\u30b9\u30bf\u30de\u30a4\u30ba<\/h3>\n
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\u52b9\u679c\u6e2c\u5b9a\u3068\u7d99\u7d9a\u306e\u30b3\u30c4<\/h2>\n
\u5ba2\u89b3\u7684\u306a\u6307\u6a19\u3067\u306e\u52b9\u679c\u6e2c\u5b9a<\/h3>\n
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\u7d30\u80de\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u6280\u8853<\/h3>\n
NAD+\u524d\u99c6\u4f53\u306e\u65b0\u4e16\u4ee3<\/h3>\n
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\n[blog_parts id=”24962″]<\/p>\n","protected":false},"excerpt":{"rendered":"